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In November, just a few days before Thanksgiving, Anthropic released Claude Opus 4.5 and naturally my coworkers were curious if it was a significant improvement over Sonnet 4.5. It was very suspicious that Anthropic released Opus 4.5 right before a major holiday since companies typically do that in order to bury underwhelming announcements as your prospective users will be too busy gathering with family and friends to notice. Fortunately, I had no friends and no family in San Francisco so I had plenty of bandwidth to test the new Opus.
，这一点在新收录的资料中也有详细论述
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该论文题目为《 Exercise alleviates cognitive dysfunction in Alzheimer’s disease mice via skeletal muscle-derived extracellular vesicles that enhance plaque clearance by microglia 》，本研究以 APP/PS1 阿尔茨海默病小鼠为模型，发现游泳运动可促进骨骼肌分泌含 miR-378a-3p 的细胞外囊泡，该囊泡能促进淀粉样蛋白斑块清除，改善小鼠认知障碍，而过表达 miR-378a-3p 的肌管来源囊泡可模拟该效果，为 AD 提供了运动模拟型治疗新策略。。关于这个话题，新收录的资料提供了深入分析